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| |  Clinical Studies and Case Reports
| Title | THC improves appetite and reverses weight loss in AIDS patients |
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| Author(s) | Dejesus E, Rodwick BM, Bowers D, Cohen CJ, Pearce D |
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| Journal, Volume, Issue | J Int Assoc Physicians AIDS Care 2007;6(2):95-100. |
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| Major outcome(s) | THC improved appetite and weight and reduced nausea |
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| | | Indication | Nausea/vomiting;Appetite loss/weight loss;HIV/AIDS | Abstract |
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| Medication | Delta-9-THC | Objective: To determine whether dronabinol affects appetite and weight status in patients living with HIV/AIDS. METHODS: A retrospective chart review was conducted to analyze weight and appetite changes and nausea status in patients with HIV/AIDS who received dronabinol for 3 to 12 months from January 11, 1993, to March 17, 2003. RESULTS: Of the 117 patients who lost weight before baseline, 63% maintained or gained weight. In patients receiving dronabinol for 1 year, the mean weight gain (+/- SD) was 3.7 +/- 10.6 lb. The percentage of patients experiencing loss of appetite decreased significantly from 71% at baseline to 26% at 1 month (P < .001) and continued to decline throughout the trial. The percentage of patients experiencing nausea at baseline (38%) decreased consistently from week 2 on; this change from baseline was significant at month 6 (P = .031). CONCLUSION: When taken for 3 months to 1 year, dronabinol significantly improves appetite and reverses weight loss in patients living with HIV/AIDS. |
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| Route(s) | Oral |
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| Dose(s) | |
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| Duration (days) | 90-365 |
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| Participants | 117 patients with HIV/AIDS |
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| Design | Open study |
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| Type of publication | Medical journal |
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| Address of author(s) | Orlando Immunology Center, Orlando, Florida, edejesus@oicorlando.com. |
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